MRI software measurement of osteophyte volume in knee osteoarthritis: a longitudinal validation study
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چکیده
Osteoarthritis (OA) currently affects 41 million Americans, and knee OA (KOA) alone causes the highest risk of mobility disability of any medical condition in people 65 years and older. There are no current treatments to reverse the degenerative changes of KOA, and research is aimed at finding biomarkers of KOA progression to aid in the development of effective therapies. Osteophytes are a hallmark feature of KOA and may act as a biomarker of joint space loss and pain progression. MR imaging, which is an accurate and non-invasive method to monitor KOA disease status, may aid in clarifying the role of osteophytes in KOA, especially using semi-automated quantitative software methods to accurately and efficiently calculate osteophyte volume in longitudinal studies. This study investigated the association of osteophyte volume change with joint space narrowing and pain progression in a randomized sample of 505 subjects from the FNIH OA Biomarker Consortium Project, a case-control study based on a larger
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تاریخ انتشار 2016